A Little pRB Can Lead to Big Problems

A little pRB can lead to big problems.

SUMMARY Germline deletion of RB1, the gene encoding the retinoblastoma tumor-suppressor protein pRB, predisposes to eye tumor formation upon loss of the remaining wild-type allele. Many functions affecting cell-cycle control, cell-cycle exit, and numerous other processes involved in the transformed phenotype have been ascribed to pRB, and deregulation of these processes is generally thought to ...

Pnm-12: Can Stress Lead to Infertility?

Background: The role that stress plays in infertility remains controversial and despite medical advances a large percentage of infertility remains unexplained. Clinicians and researchers consistently report that infertile women view infertility and its treatment as extremely stressful. Basic science has elucidated the linkages between the hypothalamic-pituitary axis (HPA) and hypothalamic-pitui...

What Big Sites Can Learn from Little Sites

Little pamphlets and big lies: federal authorities respond to childhood lead poisoning, 1935-2003.

Christian Warren, PhDa Late in 1935, Alice Hamilton, who a generation earlier had done more than any other government-sponsored researcher to expose and ameliorate industrial lead poisoning, wrote to Martha May Eliot, assistant chief of the U.S. Children’s Bureau.1 A young friend of Hamilton’s, a new mother married to a third-year medical student at Harvard, had asked Hamilton how to be sure th...

Big brains, little bodies.

www.sciencemag.org SCIENCE VOL 338 14 DECEMBER 2012 1389 COVER Arachnoscelis magnifi ca, a predaceous katydid (Orthoptera: Tettigoniidae), on a leaf in the San Lorenzo forest of Panama. This attractive insect is but one of the ~25,000 arthropod species likely to live in this 6000-hectare forest, confi rming the formidable diversity of arthropods, which appears to be 300 times that of mammals in...